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  • Chemical Biology

    Megabass Lure MARINE GANG 140S GG Rainbow F S from JAPAN opxtye3248-Crankbaits

    Item specifics

    New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is ... Read moreabout the condition






    Metal bait casting reel Drum Round fishing wheel Fishing reel 4.5 1 gear ratio

    Here’s some medicinal chemistry combined with synthetic biology for you. Many people are used to thinking in terms of finding small-molecule probes for various cell targets, and those are valuable things. But what if you want to control a certain population of (for example) ion channels, but there aren’t any compounds that will do the… Metal Fishing Lures Lead Fishing Baits Fishing Lure 10pcs 7g 10g 14g 21g 28g 40g
  • Chemical News

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    MINNKOTA Ultrex 80 Mega DI iPilot Link BT 45 Inch 1368860 I was interested to see this paper, which goes into detail on a chemical phenomenon that many have seen but no one understands very well: triboluminescence. That word meets with a blank stare or instant recognition; there’s not much in between. It means “emission of light when a material is physically broken”, and that encompasses… Metal Jig FT 220 grams SLB (6167) FCL Labo
  • Analytical Chemistry

    Metal Jig MSL 320 grams PPY (2703) FCL Labo

    I suppose I deserve this one. Some years ago on the blog, I wrote about my days in grad school having to learn about symmetries and vibrational spectroscopy. Sparingly has that knowledge come in handy since then, but the course is still a vivid memory for me, since that’s the clearest example I had yet… Read More
  • Cancer

  • Drug Assays

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    Mint Jointed Claw 178 Wounded Bass With Sign A common question – well, it should be a common question, anyway – is “How do I make sure that this compound collection is a useful one to screen?” There are alternative forms that come down to the same issues – if you’re putting together a new focused screening set, what should be in it?… Read More
  • Biological News

  • Business and Markets

  • Analytical Chemistry

    A Close Look at Fragments

    Here’s a look from the D. E. Shaw research team at fragment binding, and even if you don’t do fragment-based drug discovery, it’s worth a read. That’s because the mechanisms by which fragments bind to proteins are most likely the fundamental ones by which larger molecules bind as well; this is the reductionist look at… Read More
  • Analytical Chemistry

    A Look at Proteins in Living Cells

    We spend a lot of time in this sort of work thinking about protein structures. Traditionally that’s been the province of X-ray crystallography, later joined by solution NMR, and more latterly by cryo-electron microscopy. Each of these has its own set of advantages and disadvantages, but one big split is between the solid phase (X-ray… Metalab Junior Cow Horse Medium Twist Gag
  • Academia (vs. Industry)

    Startup Culture, Starting

    Mint Vibration Lure Set 5 color Many readers of this blog work in the biopharma industry, naturally, and of those, many are in and around the (few) locations where a great many of the companies in the industry are born. I myself am in the Boston/Cambridge area, famously thick with companies large and small, and then you have the Bay area… Metalab Mens all around spur
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