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  • Chemical Biology

    Shakespeare ATS Trolling Reel Agility 6.3 1 2 Bearings ATS30LC opkspd5028-Spinning Reels

  • Chemical News

    Shimano 09 Honootsuki (left) from japan (2191

    Shimano 17 SAHARA C2000-HGS Spinning Reel from Japan I was interested to see this paper, which goes into detail on a chemical phenomenon that many have seen but no one understands very well: triboluminescence. That word meets with a blank stare or instant recognition; there’s not much in between. It means “emission of light when a material is physically broken”, and that encompasses… Shimano 1.5 - 570 Basis ISO Rod Sports Fishing Leisure Discontinued B46
  • Analytical Chemistry

    SHIMANO 10 STELLA 2500HGS Spinning Reel USED from Japan F106

    I suppose I deserve this one. Some years ago on the blog, I wrote about my days in grad school having to learn about symmetries and vibrational spectroscopy. Sparingly has that knowledge come in handy since then, but the course is still a vivid memory for me, since that’s the clearest example I had yet… Read More
  • Cancer

  • Drug Assays

    Shimano 11 Oshia Calcutta 200HG from japan (10973

    Shimano 17 Scorpion DC 100HG right handle A common question – well, it should be a common question, anyway – is “How do I make sure that this compound collection is a useful one to screen?” There are alternative forms that come down to the same issues – if you’re putting together a new focused screening set, what should be in it?… Read More
  • Biological News

  • Business and Markets

  • Analytical Chemistry

    A Close Look at Fragments

    Here’s a look from the D. E. Shaw research team at fragment binding, and even if you don’t do fragment-based drug discovery, it’s worth a read. That’s because the mechanisms by which fragments bind to proteins are most likely the fundamental ones by which larger molecules bind as well; this is the reductionist look at… Read More
  • Analytical Chemistry

    A Look at Proteins in Living Cells

    We spend a lot of time in this sort of work thinking about protein structures. Traditionally that’s been the province of X-ray crystallography, later joined by solution NMR, and more latterly by cryo-electron microscopy. Each of these has its own set of advantages and disadvantages, but one big split is between the solid phase (X-ray… Shimano 13 Aorista BB 4000 Spinning Reel 4969363031839
  • Academia (vs. Industry)

    Startup Culture, Starting

    Shimano 17 SEDONA 4000-XG Spinning Reel from Japan F S Many readers of this blog work in the biopharma industry, naturally, and of those, many are in and around the (few) locations where a great many of the companies in the industry are born. I myself am in the Boston/Cambridge area, famously thick with companies large and small, and then you have the Bay area… Shimano 13 Biomaster SW 4000XG [Japan]
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